Rucaparib in Men With Metastatic Castration-Resistant Prostate Cancer Harboring a BRCA1 or BRCA2 Gene Alteration

Abida, W.; Patnaik, Akash; Campbell, D.; Shapiro, J.; Bryce, A.; McDermott, R.; Sautois, B.; Vogelzang, N.; Bambury, R.; Voog, E.; Zhang, Jingsong; Piulats, J.; Ryan, C.; Merseburger, A.; Daugaard, G.; Heidenreich, A.; Fizazi, K.; Higano, C.; Krieger, L.; Sternberg, C.; Watkins, S.; Despain, D.; Simmons, A.; Loehr, A.; Dowson, Melanie; Golsorkhi, Tony; Chowdhury, S.

doi:10.1200/JCO.20.01035

Public

Rucaparib in Men With Metastatic Castration-Resistant Prostate Cancer Harboring a BRCA1 or BRCA2 Gene Alteration

Shared by NobleBlocks on Aug 14, 2020 • 12:00 AM UTC

Authors:

W. Abida

Akash Patnaik

D. Campbell

Abstract

PURPOSE BRCA1 or BRCA2 (BRCA) alterations are common in men with metastatic castration-resistant prostate cancer (mCRPC) and may confer sensitivity to poly(ADP-ribose) polymerase inhibitors. We present results from patients with mCRPC associated with a BRCA alteration treated with rucaparib 600 mg t...

Subject

Medicine

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