Preoperative therapy with trastuzumab and paclitaxel followed by sequential adjuvant doxorubicin/cyclophosphamide for HER2 overexpressing stage II or III breast cancer: a pilot study.

J Burstein, Harold; N Harris, Lyndsay; Gelman, Rebecca; C Lester, Susan; A Nunes, Raquel; M Kaelin, Carolyn; M Parker, Leroy; W Ellisen, Leif; Kuter, Irene; A Gadd, Michele; L Christian, Roger; Rae Kennedy, Patricia; F Borges, Virginia; A Bunnell, Craig; Younger, Jerry; L Smith, Barbara; P Winer, Eric

doi:10.1200/JCO.2003.03.124

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Preoperative therapy with trastuzumab and paclitaxel followed by sequential adjuvant doxorubicin/cyclophosphamide for HER2 overexpressing stage II or III breast cancer: a pilot study.

Shared by NobleBlocks on Jan 1, 2003 • 12:00 AM UTC

Authors:

Harold J Burstein

Lyndsay N Harris

Rebecca Gelman

Abstract

PURPOSE: Trastuzumab combined with chemotherapy improves outcomes for women with human epidermal growth factor receptor 2 (HER2) overexpressing advanced breast cancer. We conducted a pilot study of preoperative trastuzumab and paclitaxel, followed by surgery and adjuvant doxorubicin and cyclophospha...

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