Randomized phase II trial comparing bevacizumab plus carboplatin and paclitaxel with carboplatin and paclitaxel alone in previously untreated locally advanced or metastatic non-small-cell lung cancer.

H Johnson, David; Fehrenbacher, Louis; F Novotny, William; S Herbst, Roy; J Nemunaitis, John; M Jablons, David; J Langer, Corey; F DeVore, Russell; Gaudreault, Jacques; A Damico, Lisa; Holmgren, Eric; Kabbinavar, Fairooz

doi:10.1200/JCO.2004.11.022

Public

Randomized phase II trial comparing bevacizumab plus carboplatin and paclitaxel with carboplatin and paclitaxel alone in previously untreated locally advanced or metastatic non-small-cell lung cancer.

Shared by NobleBlocks on Jun 1, 2004 • 12:00 AM UTC

Authors:

David H Johnson

Louis Fehrenbacher

William F Novotny

Abstract

PURPOSE: To investigate the efficacy and safety of bevacizumab plus carboplatin and paclitaxel in patients with advanced or recurrent non-small-cell lung cancer. PATIENTS AND METHODS: In a phase II trial, 99 patients were randomly assigned to bevacizumab 7.5 (n = 32) or 15 mg/kg (n = 35) plus carbop...

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