Phase III trial of nanoparticle albumin-bound paclitaxel compared with polyethylated castor oil-based paclitaxel in women with breast cancer.

J Gradishar, William; Tjulandin, Sergei; Davidson, Neville; Shaw, Heather; Desai, Neil; Bhar, Paul; Hawkins, Michael; O'Shaughnessy, Joyce

doi:10.1200/JCO.2005.04.937

Public

Phase III trial of nanoparticle albumin-bound paclitaxel compared with polyethylated castor oil-based paclitaxel in women with breast cancer.

Shared by NobleBlocks on Nov 1, 2005 • 12:00 AM UTC

Authors:

William J Gradishar

Sergei Tjulandin

Neville Davidson

Abstract

PURPOSE: ABI-007, the first biologically interactive albumin-bound paclitaxel in a nanameter particle, free of solvents, was compared with polyethylated castor oil-based standard paclitaxel in patients with metastatic breast cancer (MBC). This phase III study was performed to confirm preclinical stu...

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