Causal relationship between obesity and vitamin D status: bi-directional Mendelian randomization analysis of multiple cohorts.

S Vimaleswaran, Karani; J Berry, Diane; Lu, Chen; Tikkanen, Emmi; Pilz, Stefan; T Hiraki, Linda; D Cooper, Jason; Dastani, Zari; Li, Rui; K Houston, Denise; R Wood, Andrew; Michaëlsson, Karl; Vandenput, Liesbeth; Zgaga, Lina; M Yerges-Armstrong, Laura; I McCarthy, Mark; Dupuis, Josée; Kaakinen, Marika; E Kleber, Marcus; Jameson, Karen; Arden, Nigel; Raitakari, Olli; Viikari, Jorma; K Lohman, Kurt; Ferrucci, Luigi; Melhus, Håkan; Ingelsson, Erik; Byberg, Liisa; Lind, Lars; Lorentzon, Mattias; Salomaa, Veikko; Campbell, Harry; Dunlop, Malcolm; D Mitchell, Braxton; Herzig, Karl-Heinz; Pouta, Anneli; Hartikainen, Anna-Liisa; Investigation of Anthropometric Traits-GIANT Consortium, Genetic; A Streeten, Elizabeth; Theodoratou, Evropi; Jula, Antti; J Wareham, Nicholas; Ohlsson, Claes; M Frayling, Timothy; B Kritchevsky, Stephen; D Spector, Timothy; Brent Richards, J; Lehtimäki, Terho; H Ouwehand, Willem; Kraft, Peter

doi:10.1371/journal.pmed.1001383

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Causal relationship between obesity and vitamin D status: bi-directional Mendelian randomization analysis of multiple cohorts.

Shared by NobleBlocks on Jan 1, 2013 • 12:00 AM UTC

Authors:

Karani S Vimaleswaran

Diane J Berry

Chen Lu

Abstract

BACKGROUND: Obesity is associated with vitamin D deficiency, and both are areas of active public health concern. We explored the causality and direction of the relationship between body mass index (BMI) and 25-hydroxyvitamin D [25(OH)D] using genetic markers as instrumental variables (IVs) in bi-dir...

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