Modulation of genetic associations with serum urate levels by body-mass-index in humans.

JE, Huffman; E, Albrecht; A, Teumer; M, Mangino; K, Kapur; T, Johnson; Z, Kutalik; N, Pirastu; G, Pistis; LM, Lopez; T, Haller; P, Salo; A, Goel; M, Li; T, Tanaka; A, Dehghan; D, Ruggiero; G, Malerba; AV, Smith; IM, Nolte; L, Portas; A, Phipps-Green; L, Boteva; P, Navarro; A, Johansson; AA, Hicks; O, Polasek; T, Esko; JF, Peden; SE, Harris; F, Murgia; SH, Wild; A, Tenesa; A, Tin; E, Mihailov; A, Grotevendt; GK, Gislason; J, Coresh; P, D'Adamo; S, Ulivi; P, Vollenweider; G, Waeber; S, Campbell; I, Kolcic; K, Fisher; M, Viigimaa; JE, Metter; C, Masciullo; E, Trabetti; C, Bombieri; R, Sorice; A, Döring; E, Reischl; K, Strauch; A, Hofman; AG, Uitterlinden; M, Waldenberger; HE, Wichmann; G, Davies; AJ, Gow; N, Dalbeth; L, Stamp; JH, Smit; M, Kirin; R, Nagaraja; M, Nauck; C, Schurmann; K, Budde; SM, Farrington; E, Theodoratou; A, Jula; V, Salomaa; C, Sala; C, Hengstenberg; M, Burnier; R, Mägi; N, Klopp; S, Kloiber; S, Schipf; S, Ripatti; S, Cabras; N, Soranzo; G, Homuth; T, Nutile; PB, Munroe; N, Hastie; H, Campbell; I, Rudan; C, Cabrera; C, Haley; OH, Franco; TR, Merriman; V, Gudnason; M, Pirastu; BW, Penninx; H, Snieder; A, Metspalu; M, Ciullo; PP, Pramstaller; Duijn CM, van; L, Ferrucci; G, Gambaro; IJ, Deary; MG, Dunlop; JF, Wilson; P, Gasparini; U, Gyllensten; TD, Spector; AF, Wright; C, Hayward; H, Watkins; M, Perola; M, Bochud; WH, Kao; M, Caulfield; D, Toniolo; H, Völzke; C, Gieger; A, Köttgen; V, Vitart

doi:10.1371/journal.pone.0119752

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Modulation of genetic associations with serum urate levels by body-mass-index in humans.

Shared by NobleBlocks on Mar 26, 2015 • 12:00 AM UTC

Authors:

Huffman JE

Albrecht E

Teumer A

Abstract

We tested for interactions between body mass index (BMI) and common genetic variants affecting serum urate levels, genome-wide, in up to 42569 participants. Both stratified genome-wide association (GWAS) analyses, in lean, overweight and obese individuals, and regression-type analyses in a non BMI-s...

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