Common Genetic Variation In Cellular Transport Genes and Epithelial Ovarian Cancer (EOC) Risk.

Chornokur, Ganna; Lin, Hui-Yi; P Tyrer, Jonathan; Lawrenson, Kate; Dennis, Joe; K Amankwah, Ernest; Qu, Xiaotao; Tsai, Ya-Yu; S L Jim, Heather; Chen, Zhihua; Y Chen, Ann; Permuth-Wey, Jennifer; K H Aben, Katja; Anton-Culver, Hoda; Antonenkova, Natalia; Bruinsma, Fiona; V Bandera, Elisa; T Bean, Yukie; W Beckmann, Matthias; Bisogna, Maria; Bjorge, Line; Bogdanova, Natalia; A Brinton, Louise; Brooks-Wilson, Angela; H Bunker, Clareann; Butzow, Ralf; G Campbell, Ian; Carty, Karen; Chang-Claude, Jenny; S Cook, Linda; W Cramer, Daniel; M Cunningham, Julie; Cybulski, Cezary; Dansonka-Mieszkowska, Agnieszka; du Bois, Andreas; Despierre, Evelyn; Dicks, Ed; A Doherty, Jennifer; Dörk, Thilo; Dürst, Matthias; F Easton, Douglas; M Eccles, Diana; P Edwards, Robert; B Ekici, Arif; A Fasching, Peter; L Fridley, Brooke; Gao, Yu-Tang; Gentry-Maharaj, Aleksandra; G Giles, Graham; Glasspool, Rosalind

doi:10.1371/journal.pone.0128106

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Common Genetic Variation In Cellular Transport Genes and Epithelial Ovarian Cancer (EOC) Risk.

Shared by NobleBlocks on Jan 1, 2015 • 12:00 AM UTC

Authors:

Ganna Chornokur

Hui-Yi Lin

Jonathan P Tyrer

Abstract

BACKGROUND: Defective cellular transport processes can lead to aberrant accumulation of trace elements, iron, small molecules and hormones in the cell, which in turn may promote the formation of reactive oxygen species, promoting DNA damage and aberrant expression of key regulatory cancer genes. As ...

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