Caspase Inhibition Modulates Monocyte-Derived Macrophage Polarization in Damaged Tissues

Solier, S.; Mondini, M.; Meziani, L.; Jacquel, A.; Lacout, C.; Berghe, T.; Julé, Y.; Martinou, J.; Pierron, G.; Rivière, J.; Deloger, Marc; Dupuy, C.; Slama-Schwok, A.; Droin, N.; Vandenabeele, P.; Auberger, P.; Deutsch, E.; El-Benna, J.; M. Dang, P.; Solary, E.

doi:10.3390/ijms24044151

Public

Caspase Inhibition Modulates Monocyte-Derived Macrophage Polarization in Damaged Tissues

Shared by NobleBlocks on Feb 1, 2023 • 12:00 AM UTC

Authors:

S. Solier

M. Mondini

L. Meziani

Abstract

Circulating monocytes are recruited in damaged tissues to generate macrophages that modulate disease progression. Colony-stimulating factor-1 (CSF-1) promotes the generation of monocyte-derived macrophages, which involves caspase activation. Here, we demonstrate that activated caspase-3 and caspase-...

Subject

Medicine

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