Abatacept Reduces Levels of Switched Memory B Cells, Autoantibodies, and Immunoglobulins in Patients with Rheumatoid Arthritis

Scarsi, M.; Paolini, Lucia; Ricotta, D.; Pedrini, A.; Piantoni, S.; Caimi, L.; Tincani, A.; Airó, P.

doi:10.3899/jrheum.130905

Public

Abatacept Reduces Levels of Switched Memory B Cells, Autoantibodies, and Immunoglobulins in Patients with Rheumatoid Arthritis

Shared by NobleBlocks on Apr 1, 2014 • 12:00 AM UTC

Authors:

M. Scarsi

Lucia Paolini

D. Ricotta

Abstract

Objective. Abatacept (ABA) is a chimeric molecule, able to block the CD28-mediated costimulatory pathway. To evaluate the hypothesis that, through this mechanism of action, ABA may down-modulate the immune responses of B lymphocytes in rheumatoid arthritis (RA), we investigated the serum levels of i...

Subject

Medicine

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