Tracking FACT and the RNA polymerase II elongation complex through chromatin in vivo.

A, Saunders; J, Werner; ED, Andrulis; T, Nakayama; S, Hirose; D, Reinberg; JT, Lis

doi:10.1126/science.1085712

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Tracking FACT and the RNA polymerase II elongation complex through chromatin in vivo.

Shared by NobleBlocks on Aug 1, 2003 • 12:00 AM UTC

Authors:

Saunders A

Werner J

Andrulis ED

Abstract

RNA polymerase II (Pol II) transcription through nucleosomes is facilitated in vitro by the protein complex FACT (Facilitates Chromatin Transcription). Here we show that FACT is associated with actively transcribed Pol II genes on Drosophila polytene chromosomes. FACT displays kinetics of recruitmen...

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