The use of homocysteine and other metabolites in the specific diagnosis of vitamin B-12 deficiency.

P Stabler, S; Lindenbaum, J; H Allen, R

doi:10.1093/jn/126.suppl_4.1266S

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The use of homocysteine and other metabolites in the specific diagnosis of vitamin B-12 deficiency.

Published in The Journal of nutrition • Apr 1, 1996

Authors:

S P Stabler

J Lindenbaum

R H Allen

Abstract

Vitamin B-12 (cobalamin) is a cofactor for only two enzymes, methionine synthase and L-methylmalonyl-CoA mutase. The serum vitamin B-12 concentration has been shown to have limitations in specificity and sensitivity in diagnosing vitamin B-12 deficiency and predicting response to therapy in subjects...

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