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Serine Proteases Decrease Intestinal Epithelial Permeability By A PKCζ‐mediated mechanism

Published in The FASEB Journal • Apr 1, 2007
NobleIDNI7P96W07R78S86
Authors:
Veronica A. Swystun
,
Wallace K. MacNaughton

Abstract

The transport of ions and the permeability to macromolecules across the epithelium regulates fluid balance in the gastrointestinal tract. The digestive serine proteases trypsin, elastase and chymotrypsin decrease the paracellular permeability of intestinal epithelial cells to Na + , Cl − and 3000MW ...

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