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Multiple sequence alignment methods

Durbin, Eddy, Krogh

Cambridge University Press eBooks23 Apr 1998

NobleIDark:/48914/w1/20260524/EE4F5E4DDOI10.1017/cbo9780511790492.007

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Abstract

In Chapter 5, we assumed that a reasonable multiple sequence alignment was already known and provided the starting point for constructing a profile HMM. We now look at what a ‘reasonable’ multiple alignment is, and at ways to construct one automatically from unaligned sequences.

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