IC–P–087: Annualized decrease in plasma Aβ42 correlates with annualized decrease in hippocampal volume

Aβ42 deposits selectively in AD and is decreased in the CSF of patients with mild cognitive impairment (MCI) or AD. Plasma Aβ42 is increased, however, by mutations causing early onset familial AD, and Aβ42 and Aβ40 are both increased in Down syndrome, young (<65 years) AD relatives, and aging. In a ... View More