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Less stimulating environmental conditions decrease spatial learning ability and reduce GAP-43 and synaptophysin immunostaining in the hippocampal formation in adult male mice

Published in Kobe University Repository Kernel (Kobe University) • Jan 1, 2009
NobleIDNI2P19W20R84S34
Authors:
Mitsuru Miyamoto
,
Kozo Sugioka
,
Takamitsu Arakawa

Abstract

Environmental conditions affect learning ability and cause neuroanatomical alterations of neurons and synapses in the hippocampal formation. We reared male mice in standard, enriched and wheel-running environments (n = 7 in each group) as well as in an impoverished environment (n = 9) for 102 days a...

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