Following the CD-R and DVD-R manufacturing process there is typically a residual 2,2,3,3-tetrafluoro-1-propanol (TFP) content in the wastewater. However, currently available technologies to manage TFP disposal such as evaporation could only transfer pollutants from one phase to another rather than eliminate them from environment and, thus, will cause secondary pollution. Combination of the Advanced Oxidation Processes (AOP) and the adsorption will offer effective results for treating TFP as organofluoro compounds. In this study, we investigated the comparison between two commonly oxidants, hydrogen peroxide (H2O2) and persulfate (S2O82-), for mineralizing TFP. Meanwhile, the activation efficiencies of persulfate by three ways, heat, UV irradiation, and transition metal, for the mineralization of TFP were evaluated. The influences of several important reaction parameters, such as pH of solutions, dosage of H2O2 and S2O82-, lamp intensity, and temperature, on the TFP mineralization are also investigated. These issues are useful to choose and improve the performance of OH• or SO4•−generated from H2O2 or S2O82- for mineralization of TFP. In comparing H2O2 reagent with the S2O82- reagent, results showed that the mineralization rates are in the order of S2O82- > H2O2. The efficiency of TFP mineralization was 99.5%, 99.7%, and 49% for heat 800C, UV-C 254 nm, and Fe2+ activated persulfate, respectively. Furthermore, the highest TOC removal (99.7%) could be approached at the optimum conditions: [TFP]I = 1.39 mM; [S2O82-]I = 20 mM; UV-C 254 nm; reaction time = 60 min. Around 98.2-99.7% fluoride ion generated from TFP by UV-S2O82- oxidation, could then be easily adsorbed by low-cost adsorbents (waste iron oxide). Finally, in the adsorption study, results showed that kinetic adsorption can be described by the pseudo-second-order rate equation and adsorption isotherm can be described by the Langmuir model.