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Multiple Testing Methodology

Published • Dec 8, 2009
NobleIDNI8P99W19R28S95
Authors:
Alex Dmitrienko
,
Frank Bretz
,
Peter H. Westfall

Abstract

Multiplicity issues are encountered in a variety of pharmaceutical applications with multiple objectives. In a pre-clinical setting, the objectives can correspond to multiple genetic markers. In clinical applications, the objectives can be defined in terms of multiple dose levels, endpoints or subgro...

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