The proportion of men with multiple primary malignancies (MPM), by involving the prostate, is 9.3% of all the patients with prostate cancer in the Altai Territory. When prostate cancer is found, the lung, skin, oral cavity, and digestive tract should be examined to reveal secondary tumors. When primary malignancy is detected in these organs, the prostate should be more meticulously examined. In patients with double metachronic nonsystemic MPM with the involvement of the prostate, the disease is more frequently detectable in the 60-69 year age group.