Endcapped antisense oligonucleotides decrease chromaffin cell scinderin expression and stimulation-evoked F-actin disassembly and exocytosis.

We have recently designed a 20-mer scinderin phosphorothioate endcapped substituted antisense oligodeoxynucleotide (ODN) sequence, which encompasses the scinderin initiation (ATG) site, and evaluated its impact on scinderin expression and amine output from cultured chromaffin cells. Chromaffin cells... View More