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Proteasome Inhibitors Decrease AAV2 Capsid-Derived Peptide Epitope Presentation On MHC Class I Following Transduction.

Published in Blood • Nov 20, 2009
NobleIDNI1P61W54R35S04
Authors:
Jonathan D. Finn
,
Daniel J. Hui
,
Downey Harre

Abstract

Abstract Abstract 695 Adeno-associated viral (AAV) vectors are one of the most extensively studied and highly used vector platforms for gene therapy applications. We have recently provided evidence for AAV capsid-derived antigen presentation through MHC class I on the surface of AAV-transduced cells...

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