整合素连接激酶和肾小管-间质纤维化

陈廷芳; Chen, Ming

doi:10.3760/cma.j.issn.1673-4238.2006.02.015

From the research index

The paper comes from the research index. It wasn’t submitted here.

Journal article

整合素连接激酶和肾小管-间质纤维化

陈廷芳, Ming Chen

国际移植与血液净化杂志20 Mar 2006

Journal articleFrom the research index

整合素连接激酶和肾小管-间质纤维化

陈廷芳, Ming Chen · 国际移植与血液净化杂志 · 20 Mar 2006

Abstract

No PDF here

The full text is at the publisher

You can read the abstract here, or open it at the publisher.

Read at the publisher

整合素连接激酶(Integrin-linked kinase,ILK)是一种近期发现的Ser/Thr蛋白激酶.ILK能够通过与整合素β1亚单位的结合介导细胞与胞外基质的连接,以依赖于PI3K的方式激活,并通过磷酸化下游底物PKB/AKT、GSK3等使胞外信号得以向下游传递,参与多种信号传导通路,与肾间质纤维化的发生相关。