血清GPC3联合AFP对原发性肝癌的诊断价值探讨
Published in Zhonghua jianyan yixue zazhi • Oct 11, 2007
Authors:,,
汪得胜
Ding Hui guo
Li Zhuo
Abstract
原发性肝癌早期诊断是改善预后的关键[1].AFP联合肝脏超声筛查和随访是早期诊断的主要途径,但对慢性肝病基础上较为常见的良性病变与小肝癌的鉴别仍较困难[2].AFP≥200μg/L作为诊断肝癌临界值(cut-off值),敏感度仅为20%～45%[3].AFP异质体(AFP-L3)检测等对肝癌有很好的特异度,但是敏感度也低[4].磷脂酰肌醇硫酸类肝素蛋白聚糖3(glypican-3,GPC3)是通过磷脂酰肌醇(GPI)锚定于细胞膜表面脂质的硫酸类肝素蛋白聚糖,参与调节胚胎生长发育.
Subject
Finding related papers...
Discussions
(0)No comments yet
Be the first to share your thoughts!