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异丙酚对阿霉素诱发大鼠离体心肌细胞凋亡的影响
吴双全, 张瑞华, 王福莹 and 1 other
Zhonghua mazuixue zazhi20 Aug 2009
NobleIDark:/48914/w1/20260515/CDBC6B40DOI10.3760/cma.j.issn.0254-1416.2009.08.022
Journal article
异丙酚对阿霉素诱发大鼠离体心肌细胞凋亡的影响
吴双全, 张瑞华, 王福莹 and 1 other · Zhonghua mazuixue zazhi · 2009 · Subscription
NobleIDark:/48914/w1/20260515/CDBC6B40DOI10.3760/cma.j.issn.0254-1416.2009.08.022
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Abstract
阿霉素是临床常用抗肿瘤药物.研究表明,阿霉素可诱发心肌细胞凋亡,引起阿霉素性心肌病,早期出现心律失常,晚期出现充血性心力衰竭[1].异丙酚可降低脂质过氧化产物生成,抑制细胞凋亡,减轻心肌缺血再灌注损伤[2].本研究拟通过评价异丙酚对阿霉素诱发大鼠离体心肌细胞凋亡的影响,探讨异丙酚对心肌细胞的保护作用。