Following the success of the 1st Workshop in the series held on March 5–6, 2018 in Hong Kong. The 2nd IEEE International Workshop on System Biology and Biomedical Systems isagain sponsored by the IEEE Systems Council and the IEEE Consumer Electronics Society's Hong Kong Section. The focus of this workshop is the system biology aspects of consumer healthcare devices, reliability, and optimization on assistive and preventive care solutions. The Workshop features twelve speakers from industry and universities in China, Hong Kong, Japan, Portugal, Taiwan and the USA.