The e-learning programs are delivered through the network to the learner's computer, either ahead of the actual learning experience, or just as the learner is engaging in the learning; this leads to a number of instructional design advantages. Asynchronous e-learning is e-learning done in a self-instructional mode. The design process for asynchronous e-learning is basically the same as that of a classroom design, except that the design steps must be more rigorous. This chapter helps to differentiate between asynchronous and synchronous e-learning, and determine what planning must be done by the organization in advance of designing an asynchronous e-learning program. It helps to formulate basic criteria for choosing a learning management system, and analyze the offerings of e-learning vendors. The chapter also helps to develop effective, activity-based asynchronous e-learning programs, prepare the learners for the self-direction necessary in asynchronous e-learning, and properly implement and evaluate asynchronous e-learning programs.