This introduction presents an overview of the key concepts discussed in the subsequent chapters of this book. The book presents a special collection of empirical papers, critical commentaries/reviews, and a book review in the International Journal of Transgenderism. The impetus for the book was the plethora of recent troubling legislation that have limited and removed sundry rights of transgender individuals. As a result of divisive rhetoric, transgender youth often face particular challenges related to acceptance by their families, at school, and in the larger community. Among 10 contributions, 6 are empirical papers. The collection of these papers approached resiliency from multiple lenses – from school-based clubs as tools for engagement in advocacy, to proactivity and self-care as strategies to mitigate struggles. These empirical articles focused on diverse contexts, including school, the media, and religious contexts.