Member States in the UNECE/WHO European Region established the Transport, Health and Environment Pan European Programme (THE PEP) in 2002. It is an intersectoral and intergovernmental policy framework and it aims to promote mobility and transport strategies that integrate environmental and health concerns. THE PEP has developed, over the years, implementation mechanisms to support the work of member States. One of those mechanisms comprises THE PEP Partnerships. THE PEP Partnerships provide a means by which member States and other stakeholders can work together in greater depth on specific issues and develop tools, methods and other resources to support policy implementation. This publication takes stock of the work done by the Partnerships, and the results achieved, and provides a clear basis for discussions on their future during the Fifth Meeting of the High-level Meeting on Transport, Health and Environment (Vienna, 22–24 October 2019).