Background.Today, the attention of domestic and foreign researchers is attracted by the problem of comprehensive (physical, mental, social and labor) rehabilitation of persons who took part in hostilities.Of particular interest is the study of psychopathological, psychological, psychosocial characteristics and mechanisms of development of decompensation and maladjustment in combatants who, during their service, are exposed to multidirectional negative influences, the combined influence of which on mental health leads to the development of polymorphic and highly comorbid pathology, which poses the task of modern researchers to study disorders associated with participation in combat operations, to increase their detection and develop effective approaches to psychopharmacotherapy and rehabilitation Objective: to study the clinical and therapeutic features of mental disorders that develop under the influence of specific factors in a combat situation, using the example of patients at the Mental Health Research Institute of the Tomsk National Medical Research Center undergoing rehabilitation after participating in armed conflicts.Material and Methods.The research sample consisted of men (n=20) with an average age of 45 years (29.5;51.75).Results.In accordance with the ICD-10 criteria, in the sample of combatants the following were diagnosed with the highest frequency: post-traumatic stress disorder (F43.1)-45%, adaptive reaction disorder (F43.2) -25%.Comorbidity with cerebral-organic pathology (organic, including symptomatic, mental disorders, F00-F09 according to ICD-10) was revealed -15%.In the syndromic aspect, sleep disturbances (95%) with nightmares (60%), a feeling of internal tension and decreased mood (85%), irritability (80%) were noted.According to the results of psychopathological, pathopsychological and neurological examination of combatants, a decrease in social adaptation (40%), organic cognitive impairment (45%), and symptoms of neurological diseases (50%) were found.Antidepressive therapy is used in personalized patient management programs: AIZS -41.2%, SSRIs -35.3%, TCAs (17.6%), often in combination with an antipsychotic (50%).Conclusion.The high comorbidity and clinical polymorphism of mental disorders among combatants dictates the need to use a wide arsenal of diagnostic, psychopharmacological and psychotherapeutic tools to provide highly qualified personalized care to each patient