This research aimed to investigate the antioxidant properties, total phenolic content, and antibacterial activity of Centotheca lappacea extract. The antioxidant activity was evaluated using the DPPH assay, total phenolic content was analyzed by the Folin-Ciocalteu method, and the antibacterial activity was tested using the disc diffusion method. The minimum inhibitory concentration (MIC) and minimum bactericidal concentration (MBC) were determined to assess the extract's efficacy against bacteria. The results showed that C. lappacea extract exhibited significant antioxidant activity with an IC50 value of 21.182 µg/ml and a total phenolic content of 16.61 mg GAE/g extract. It effectively inhibited the growth of Streptococcus pyogenes with an inhibition zone, MIC, and MBC of 19.33±1.15 mm, 125 µg/ml, and 125 µg/ml, respectively. However, it did not inhibit the growth of Escherichia coli, Staphylococcus aureus, Klebsiella pneumoniae, and Pseudomonas aeruginosa. These findings demonstrate that C. lappacea extract possesses antioxidant properties and exhibits antibacterial activity against S. pyogenes, suggesting its potential as a natural therapeutic agent.