At present, China is undergoing a rapid development of urbanization. The amount and scale of megacities are increasing at an amazing velocity, resulting that the single centre developmental pattern cannot meet the requirement of megacity. The present paper, in this context, elaborates the concept and characteristic of multicentre developmental pattern of megacity employing the fundamental principles of biology. It further investigates the issue, how to achieve the multicentre developmental pattern of megacity, so as to optimize the layout design of Chinese megacities.