pymetadata is a collection of python utilities for working with metadata in the context of COMBINE standards with source code available from available from https://github.com/matthiaskoenig/pymetadata Features include among othersannotation classes and helpers If you have any questions or issues please open an issue FundingMatthias König is supported by the Federal Ministry of Education and Research (BMBF, Germany) within the research network Systems Medicine of the Liver ( LiSyM , grant number 031L0054) and by the German Research Foundation (DFG) within the Research Unit Programme FOR 5151 QuaLiPerF (Quantifying Liver Perfusion-Function Relationship in Complex Resection - A Systems Medicine Approach)" by grant number 436883643.