RhoC knockdown decrease cellular migration and is rescued by ectopic RhoC overexpression

(492081), Ningfeng Fiona Li; (176601), Emilios Gemenetzidis; (492082), Francis J. Marshall; (492083), Derek Davies; (492084), Yongwei Yu; (492085), Kristopher Frese; (492086), Fieke E. M. Froeling; (492087), Adam K. Woolf; (492088), Roger M. Feakins; (213438), Yoshiki Naito; (117065), Christine Iacobuzio-Donahue; (428593), David A. Tuveson; (235967), Ian R. Hart; (492089), Hemant M. Kocher

doi:10.1371/journal.pone.0081575.g003

Public

RhoC knockdown decrease cellular migration and is rescued by ectopic RhoC overexpression.

Published in Figshare • Dec 2, 2015

NobleIDNI5P05W17R56S67

Authors:

Ningfeng Fiona Li (492081)

,

Emilios Gemenetzidis (176601)

,

Francis J. Marshall (492082)

Abstract

<div><p>Initial screen of PDAC cell lines revealed high expression levels of RhoC protein in HPAF and Panc0403 pancreatic cancer cells. Endogenous RhoC was silenced using shRNA (<a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0081575#pone.0081575.s006" target="_blank">Figures S...

Subject

RhoC

Cell migration

Gene knockdown

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