Model

(2922024), Randall A. Dass; (573525), Aishe A. Sarshad; (2922033), Brittany B. Carson; (2922027), Jennifer M. Feenstra; (539697), Amanpreet Kaur; (589226), Ales Obrdlik; (2922021), Matthew M. Parks; (2922039), Varsha Prakash; (2922030), Damon K. Love; (84915), Kristian Pietras; (386029), Rosa Serra; (6615), Scott C. Blanchard; (393101), Piergiorgio Percipalle; (597772), Anthony M. C. Brown; (2922036), C. Theresa Vincent

doi:10.1371/journal.pgen.1006217.g006

Public

Model.

Published in Figshare • Aug 9, 2016

NobleIDNI5P39W68R09S95

Authors:

Randall A. Dass (2922024)

,

Aishe A. Sarshad (573525)

,

Brittany B. Carson (2922033)

Abstract

<p>In breast cancer cells, Wnt5a functions as tumor suppressor by inducing Pol I transcriptional repression through nucleolar accumulation of the downstream effector DVL1. In the presence of Wnt5a, DVL1 rapidly accumulates in the nucleolus where it binds to the rDNA transcription unit. DVL1 recruitm...

Subject

Nucleolus

Effector

Transcription (linguistics)

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