<p>a) Box and whisker plot (indicating the median, 25% and 75% percentiles, and range of the variations in the sub-volumes) of canalicular densities (Can.Dn) from anterior and posterior cortices in the loaded (left) and non-loaded (right) tibiae from the three mice (M1-M3). b) Average canalicular densities (Can.Dn) evaluated in the newly formed regions (AE: Anterior Endosteal, PE: Posterior Endosteal; PP: Posterior Periosteal) and the pre-existing regions (Mid: Mid cortex). Note, we did not analyse the PP in the non-loaded tibia, nor the anterior posterior (AP) region in either the loaded or non-loaded tibia due to the limited amount of newly formed bone present.</p>