This paper presents the results of profound anamnestic and clinical and laboratory examination of 425 children with atopic dermatitis living on the environmentally rough territories. The authors present the pathogenetically substantiated requirements of optimization of standard approaches to treatment of children with allergic skin diseases living in the industrial toxic chemicals’ polluted and contaminated environment. It is proposed to use the enterosorbents and intravenous drop infusions of Cytoflavin at age-adjusted doses. Based on comparative analysis of dynamics of clinical and laboratory parameters that reflect the sensitization levels and state of oxidative homeostasis and immune system, the clinical efficacy of the drug with antioxidant, antihypoxic and metabolic action has been proven for treatment of atopic dermatitis in children living in environmentally unfavorable conditions.