Research indexAnimal study
Model.
(18709048), (21094583), (21094586) and 2 others
Figshare15 Apr 2025Open access
Animal studyOpen access
Model.
(18709048), (21094583), (21094586) and 2 others · Figshare · 2025
Free to read at the publisher
You can read the abstract here, or the full text at the publisher.
Abstract
Transcriptional and phenotypic analysis of the Rx > cre Myrf fl/fl mice suggests Myrf is downstream of Pax6 and Mitf in the hierarchy of RPE transcription factor regulation. Myrf is important for the activation of Sox10 which may impact RPE cell survival, Ermn and Upk3b , which may regulate ultrastructural organization of the RPE, and BMP/TGFB signaling, which may influence eye growth or RPE dysfunction.