Mechanically Regulated Cranial Growth in Infancy: A Computational Approach to Predicting Craniosynostosis
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Shared by Gary on Nov 1, 2025 • 12:41 AM UTC
NobleBlocks IDNB2097740A
Authors:,,
Mahtab Vafaeefar1
Ted J. Vaughan1
Conall Quinn1
Abstract
In early years of life, the cranium rapidly changes in size and shape to accommodate brain growth, primarily driven by mechanical stress from brain expansion. Developmental d isorders such as premature fusion of sutures in craniosynostosis, disrupt s normal growth process , leading to abnormal skull...
Highlights
-Mechanically driven growth model coupling brain expansion with skull and sutural bone formation.
-Allows continuous, coupled simulation of intercranial volume growth and calvarial development over 12 months.
-Predicts craniosynostosis-associated dysmorphologies with agreement to clinical observations.
-Incorporates evolving tissue properties and bulk bone formation to capture long-term growth dynamics.
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