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Enkephalin levels decrease in rat striatum during morphine abstinence.

Published in European journal of pharmacology • Dec 20, 1979
NobleIDNI3P09W38R49S23
Authors:
L Bergström
,
L Terenius

Abstract

Male Sprague-Dawley rats were treated with morphine for 11 days. Saline-injected animals served as controls. The striatal enkephalin levels were measured with a radioimmunoassay 2, 24 and 48 h after withdrawal. There was no change 2 h after the last morphine injection, but a marked reduction after 2...

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