Ketamine does not decrease striatal dopamine D2 receptor binding in man

Aalto, Sargo; Hirvonen, Jussi; Kajander, Jaana; Scheinin, Harry; Någren, Kjell; Vilkman, Harry; Gustafsson, Lars; Syvälahti, Erkka; Hietala, Jarmo

doi:10.1007/s00213-002-1236-6

Public

Ketamine does not decrease striatal dopamine D2 receptor binding in man.

Published in Psychopharmacology • Dec 1, 2002

NobleIDNI3P85W44R89S42

Authors:

Sargo Aalto

,

Jussi Hirvonen

,

Jaana Kajander

Abstract

RATIONALE: A glutamate-dopamine interaction has been implicated in the psychosis-like effects of glutamate N-methyl- D-aspartate (NMDA) receptor antagonists, such as phencyclidine and ketamine. However, recent imaging studies addressing striatal glutamate-dopamine interaction directly in vivo in man...

Discussions