Reconstituted Extracellular Vesicles from Human Platelets Decrease Viral Myocarditis in Mice.

J Beetler, Danielle; A Bruno, Katelyn; M Watkins, Molly; Xu, Vivian; Chekuri, Isha; Giresi, Presley; N Di Florio, Damian; R Whelan, Emily; H Edenfield, Brandy; A Walker, Sierra; C Morales-Lara, Andrea; R Hill, Anneliese; Jain, Angita; E Auda, Matthew; P Macomb, Logan; A Shapiro, Kathryn; C Keegan, Kevin; Wolfram, Joy; Behfar, Atta; G Stalboerger, Paul; Terzic, Andre; Farres, Houssam; T Cooper, Leslie; Fairweather, DeLisa

doi:10.1002/smll.202303317

Public

Reconstituted Extracellular Vesicles from Human Platelets Decrease Viral Myocarditis in Mice.

Published in Small (Weinheim an der Bergstrasse, Germany) • Dec 1, 2023

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Authors:

Danielle J Beetler

,

Katelyn A Bruno

,

Molly M Watkins

Abstract

Patients with viral myocarditis are at risk of sudden death and may progress to dilated cardiomyopathy (DCM). Currently, no disease-specific therapies exist to treat viral myocarditis. Here it is examined whether reconstituted, lyophilized extracellular vesicles (EVs) from platelets from healthy men...

Subject

TLR4

cardiomyopathy

complement

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