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Citrus IntegroPectin bioconjugates induce apoptosis, decrease proliferation, reduce reactive oxygen species, alleviate mitochondrial oxidative stress, upregulate miR-146 expression and downregulate expression of Interleukin-8 in lung cancer cells

Published in bioRxiv • Oct 7, 2025
NobleIDNI9P67W19R84S92
Authors:
D’Anna C
,
Di Sano C
,
Li Petri G

Abstract

Tested on adenocarcinoma A549 cell line, IntegroPectin bioconjugates derived from the industrial processing waste of different organically grown Citrus fruits exert a pleiotropic activity in their anticancer mechanism by targeting different molecular pathways. This study shows that these novel bioco...

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