Calcium pretreatment induces the decrease in epidermal growth factor binding through the activation of transglutaminase in isolated liver membrane

Katoh, S; Hashimoto, M; Kohno, H; Ohkubo, Y

doi:10.1006/abbi.1993.1304

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Calcium pretreatment induces the decrease in epidermal growth factor binding through the activation of transglutaminase in isolated liver membrane.

Published in Archives of biochemistry and biophysics • Jun 1, 1993

NobleIDNI9P30W61R49S06

Authors:

S Katoh

,

M Hashimoto

,

H Kohno

Abstract

Pretreatment of hepatocytes with Ca2+ and A23187 resulted in the decrease in epidermal growth factor (EGF) binding to the receptor. This decrease could be induced by only the pretreatment of the isolated liver membrane with Ca2+. By the pretreatment with 1 mM Ca2+ for 30 min, EGF binding was decreas...

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