IFN-gamma and TNF-alpha decrease serotonin transporter function and expression in Caco2 cells.
Published in American journal of physiology. Gastrointestinal and liver physiology • Mar 1, 2007
Authors:,,
Kevin F Foley
Cristen Pantano
Allison Ciolino
Abstract
Recent studies have shown that mucosal serotonin (5-HT) transporter (SERT) expression is decreased in animal models of colitis, as well as in the colonic mucosa of humans with ulcerative colitis and irritable bowel syndrome. Altered SERT function or expression may underlie the altered motility, secr...
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