Age-Associated Decrease in TLR Function in Primary Human Dendritic Cells Predicts Influenza Vaccine Response

Panda, Alexander; Qian, Feng; Mohanty, Subhasis; van Duin, David; K Newman, Frances; Zhang, Lin; Chen, Shu; Towle, Virginia; B Belshe, Robert; Fikrig, Erol; G Allore, Heather; R Montgomery, Ruth; C Shaw, Albert

doi:10.4049/jimmunol.0901022

Public

Age-Associated Decrease in TLR Function in Primary Human Dendritic Cells Predicts Influenza Vaccine Response

Published in The Journal of Immunology • Mar 1, 2010

NobleIDark:/48914/w1/20260526/FB79E82DRecord on NobleID

Authors:

Alexander Panda

,

Feng Qian

,

Subhasis Mohanty

Abstract

Abstract We evaluated TLR function in primary human dendritic cells (DCs) from 104 young (age 21–30 y) and older (≥65 y) individuals. We used multicolor flow cytometry and intracellular cytokine staining of myeloid DCs (mDCs) and plasmacytoid DCs (pDCs) and found substantial decreases in older compa...

Discussions