Ovariectomy and subchronic estradiol-17 beta administration decrease dopamine D1 and D2 receptors in rat striatum

JA, Tonnaer; T, Leinders; AM, van Delft

doi:10.1016/0306-4530(89)90046-2

Public

Ovariectomy and subchronic estradiol-17 beta administration decrease dopamine D1 and D2 receptors in rat striatum.

Published in Psychoneuroendocrinology • Jan 1, 1989

Authors:

Tonnaer JA

,

Leinders T

,

van Delft AM

Abstract

Ovariectomy and subchronic estradiol-17 beta cause a down-regulation of dopamine D1 and, to a lesser extent, D2 receptors in rat striatum. An intracellular mechanism mediates the DA receptor down-regulation, as various estrogens do not interact with membrane-bound DA receptors in vitro. A common den...

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