Milk could decrease the bioavailability of 6-mercaptopurine.
Published in The American journal of pediatric hematology/oncology • Jan 1, 1989
Authors:,,
Rivard GE
Lin KT
Leclerc JM
Abstract
The bioavailability of 6-mercaptopurine (6-MP) administered orally for maintenance therapy of children with acute lymphoblastic leukemia is highly variable. Xanthine oxidase (XO) can transform 6-MP into 6-thioxanthine (6-TX) and 6-thiouric acid (6-TUA), which have no therapeutic value. XO is found i...
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