Profound and persistent decrease of circulating dendritic cells is associated with ICU-acquired infection in patients with septic shock

Grimaldi, D; Louis, S; Pène, F; Sirgo, G; Rousseau, C; Claessens, Y E; Vimeux, L; Cariou, A; Mira, J P; Hosmalin, A; Chiche, J D

doi:10.1007/s00134-011-2306-1

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Profound and persistent decrease of circulating dendritic cells is associated with ICU-acquired infection in patients with septic shock.

Published in Intensive care medicine • Sep 1, 2011

Authors:

D Grimaldi

,

S Louis

,

F Pène

Abstract

PURPOSE: Septic shock induces a decrease in dendritic cells (DCs) that may contribute to sepsis-induced immunosuppression. We analyzed the time course of circulating DCs in patients with septic shock and its relation to susceptibility to intensive care unit (ICU)-acquired infections. METHODS: We enr...

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