Downregulation of Sp1 by Minnelide leads to decrease in HSP70 and decrease in tumor burden of gastric cancer

Arora, Nivedita; Alsaied, Osama; Dauer, Patricia; Majumder, Kaustav; Modi, Shrey; Giri, Bhuwan; Dudeja, Vikas; Banerjee, Sulagna; Hoff, Daniel Von; Saluja, Ashok

doi:10.1371/journal.pone.0171827

Public

Downregulation of Sp1 by Minnelide leads to decrease in HSP70 and decrease in tumor burden of gastric cancer.

Published in PloS one • Jan 1, 2017

NobleIDNI7P68W23R28S55

Authors:

Nivedita Arora

,

Osama Alsaied

,

Patricia Dauer

Abstract

BACKGROUND: Gastric cancer is the third leading cause of cancer related mortality worldwide with poor survival rates. Even though a number of chemotherapeutic compounds have been used against this disease, stomach cancer has not been particularly sensitive to these drugs. In this study we have evalu...

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