Decrease in VEGF Expression Induces Intussusceptive Vascular Pruning

Hlushchuk, Ruslan; Ehrbar, Martin; Reichmuth, Philipp; Heinimann, Niklas; Styp-Rekowska, Beata; Escher, Robert; Baum, Oliver; Lienemann, Philipp; Makanya, Andrew; Keshet, Eli; Djonov, Valentin

doi:10.1161/atvbaha.111.231811

Public

Decrease in VEGF Expression Induces Intussusceptive Vascular Pruning

Published in Arteriosclerosis, Thrombosis, and Vascular Biology • Dec 1, 2011

NobleIDNI6P78W86R84S62

Authors:

Ruslan Hlushchuk

,

Martin Ehrbar

,

Philipp Reichmuth

Abstract

Objective— The concept of vascular pruning, the “cuting-off” of vessels, is gaining importance due to expansion of angio-modulating therapies. The proangiogenic effects of vascular endothelial growth factor (VEGF) are broadly described, but the mechanisms of structural alterations by its downregulat...

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