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Environmentally relevant depleted uranium exposure damages mitochondria, decreases cytosolic reductive capacity, and increases global DNA damage accumulation through a ROS-independent mechanism involving slingshot protein phosphatase 1b enrichment

Published • Jul 8, 2026
Authors:
Phillip H. Kalaniopio
,
Luke B. Gibbons
,
Ronald S. Allen

Abstract

ABSTRACT Depleted uranium (DU) is an environmental contaminant with a 30 µg/L (ppb; parts per billion) EPA maximum contaminant level (MCL) for drinking water. The mining of uranium and use of DU in modern weapons underly human exposure that disproportionally impacts military and tribal communities i...

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